Edge of Scotoma Sensitivity as a Microperimetry Clinical Trial End Point in USH2A Retinopathy.

ABSTRACT:

Purpose

Microperimetry is commonly used to assess retinal function. We perform cross-sectional and longitudinal analysis on microperimetry parameters in USH2A retinopathy and explore end points suitable for future clinical trials.

Methods

Microperimetry was performed using two grids, Grid 1 (18° diameter) and Grid 2 (6° diameter). In Grid 1, four parameters (number of nonscotomatous loci, mean sensitivity [MS], responding point sensitivity [RPS], and edge of scotoma sensitivity [ESS]) were analyzed. In Grid 2, number of nonscotomatous loci and MS were examined. Interocular symmetry was also examined. Longitudinal analysis was conducted in a subset of eyes.

Results

Microperimetry could be performed in 16 of 21 patients. In Grid 1 (n = 15; average age, 35.

SUBMITTER: Charng J 

PROVIDER: S-EPMC7488629 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature