On the dynamical aspects of local translation at the activated synapse.

ABSTRACT:

Background

The key role in the dynamic regulation of synaptic protein turnover belongs to the Fragile X Mental Retardation Protein, which regulates the efficiency of dendritic mRNA translation in response to stimulation of metabotropic glutamate receptors at excitatory synapses of the hippocampal pyramidal cells. Its activity is regulated via positive and negative regulatory loops that function in different time ranges, which is an absolute factor for the formation of chaotic regimes that lead to disrupted proteome stability. The indicated condition may cause a number of neuropsychiatric diseases, including autism and epilepsy. The present study is devoted to a theoretical analysis of the local translation system dynamic properties and identification of parameters affecting the cha

SUBMITTER: Khlebodarova TM 

PROVIDER: S-EPMC7488754 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature