BK polyomavirus infection promotes growth and aggressiveness in bladder cancer.

ABSTRACT:

Background

Recent studies have confirmed the integration of the BK polyomavirus (BKPyV) gene into the cellular genome of urothelial carcinomas in transplant recipients, further confirming the correlation between BKPyV and urothelial carcinomas after transplantation. However, the role BKPyV infections play in the biological function of bladder cancer remains unclear.

Methods

We developed a BKPyV-infected bladder cancer cell model and a mice tumor model to discuss the role of BKPyV infections.

Results

Our research proves that BKPyV infections promote the proliferation, invasion and migration of bladder cancer cells, while the activation of β-catenin signaling pathway is one of its mediation mechanisms.

Conclusions

We first described BKPyV infection promotes the p

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC7488779 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature