Paternal DNA Methylation May Be Associated With Gestational Age at Birth.

ABSTRACT:

Background

How epigenetic modifications of DNA are associated with gestational age at birth is not fully understood. We investigated potential effects of differential paternal DNA methylation (DNAm) on offspring gestational age at birth by conducting an epigenome-wide search for cytosine-phosphate-guanine (CpG) sites.

Methods

Study participants in this study consist of male cohort members or partners of the F1-generation of the Isle of Wight Birth Cohort (IoWBC). DNAm levels in peripheral blood from F1-fathers (n = 92) collected around pregnancy of their spouses were analyzed using the Illumina 450K array. A 5-step statistical analysis was performed. First, a training-testing screening approach was applied to select CpG sites that are potentially associated with gestational

SUBMITTER: Luo R 

PROVIDER: S-EPMC7488897 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature