Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas.

ABSTRACT:

Background

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA-binding protein that is aberrantly expressed in cancers. We and others have previously shown that reduced hnRNP K expression downmodulates tumor-suppressive programs. However, overexpression of hnRNP K is the more commonly observed clinical phenomenon, yet its functional consequences and clinical significance remain unknown.

Methods

Clinical implications of hnRNP K overexpression were examined through immunohistochemistry on samples from patients with diffuse large B-cell lymphoma who did not harbor MYC alterations (n = 75). A novel transgenic mouse model that overexpresses hnRNP K specifically in B cells was generated to directly examine the role of hnRNP K overexpression in mice (three transgenic line

SUBMITTER: Gallardo M 

PROVIDER: S-EPMC7489062 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature