Blood DNA Methylation and Breast Cancer: A Prospective Case-Cohort Analysis in the Sister Study.

ABSTRACT:

Background

Peripheral blood DNA methylation may be associated with breast cancer, but studies of candidate genes and global and genome-wide DNA methylation have been inconsistent.

Methods

We performed an epigenome-wide study using Infinium HumanMethylation450 BeadChips with prospectively collected blood DNA samples from the Sister Study (1552 cases, 1224 subcohort). Differentially methylated cytosine-phosphate-guanine sites (dmCpGs) were identified using case-cohort proportional hazard models and replicated using deposited data from European Prospective Investigation into Cancer and Nutrition in Italy (EPIC-Italy) (n = 329). The correlation between methylation and time to diagnosis was examined using robust linear regression. Causal or consequential relationships of methylat

SUBMITTER: Xu Z 

PROVIDER: S-EPMC7489106 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature