Effect and cost-effectiveness of national gastric cancer screening in Japan: a microsimulation modeling study.

ABSTRACT:

Background

A national endoscopic screening program for gastric cancer was rolled out in Japan in 2015. We used a microsimulation model to estimate the cost-effectiveness of current screening guidelines and alternative screening strategies in Japan.

Methods

We developed a microsimulation model that simulated a virtual population corresponding to the Japanese population in risk factor profile and life expectancy. We evaluated 15 endoscopic screening scenarios with various starting ages, stopping ages, and screening intervals. The primary outcomes were quality-adjusted life-years (QALYs), costs, and incremental cost-effectiveness ratio. Cost-effective screening strategies were determined using a willingness-to-pay threshold of $50,000 per QALY gained. One-way sensitivity and pr

SUBMITTER: Huang HL 

PROVIDER: S-EPMC7489209 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature