Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery: A Randomized Clinical Trial.

ABSTRACT:

Importance

In patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear.

Objective

To determine whether low-tidal-volume ventilation compared with conventional ventilation during major surgery decreases postoperative pulmonary complications.

Design, setting, and participants

Single-center, assessor-blinded, randomized clinical trial of 1236 patients older than 40 years undergoing major noncardiothoracic, nonintracranial surgery under general anesthesia lasting more than 2 hours in a tertiary hospital in Melbourne, Australia, from February 2015 to February 2019. The last date of follow-up was February 17, 2019.

Interventions

Patients were randomized to receive a tidal volume of 6 mL/kg predicted body weight (n = 614; low tidal

SUBMITTER: Karalapillai D 

PROVIDER: S-EPMC7489812 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature