Intracranial Hypertension and Cerebral Perfusion Pressure Insults in Adult Hypertensive Intraventricular Hemorrhage: Occurrence and Associations With Outcome.

ABSTRACT:

Objectives

Elevated intracranial pressure and inadequate cerebral perfusion pressure may contribute to poor outcomes in hypertensive intraventricular hemorrhage. We characterized the occurrence of elevated intracranial pressure and low cerebral perfusion pressure in obstructive intraventricular hemorrhage requiring extraventricular drainage.

Design

Prospective observational cohort.

Setting

ICUs of 73 academic hospitals.

Patients

Four hundred ninety-nine patients enrolled in the CLEAR III trial, a multicenter, randomized study to determine if extraventricular drainage plus intraventricular alteplase improved outcome versus extraventricular drainage plus saline.

Interventions

Intracranial pressure and cerebral perfusion pressure were recorded every 4 hours

SUBMITTER: Ziai WC 

PROVIDER: S-EPMC7490004 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature