Construction of Potential miRNA-mRNA Regulatory Network in COPD Plasma by Bioinformatics Analysis.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) has become a major cause of morbidity and mortality worldwide. Increasing evidence indicates that aberrantly expressed microRNAs (miRNAs) are involved in the pathogenesis of COPD. However, an integrative exploration of miRNA-mRNA regulatory network in COPD plasma remains lacking.

Methods

The microarray datasets GSE24709, GSE61741, and GSE31568 were downloaded from the GEO database and analyzed using GEO2R tool to identify differentially expressed miRNAs (DEMs) between COPD and normal plasma. The consistently changing miRNAs in the three datasets were screened out as candidate DEMs. Potential upstream transcription factors and downstream target genes of candidate DEMs were predicted by FunRich and miRNet, respectively. N

SUBMITTER: Zhu M 

PROVIDER: S-EPMC7490070 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature