Preoperative Administration of Extended-Release Dinalbuphine Sebacate Compares with Morphine for Post-Laparoscopic Cholecystectomy Pain Management: A Randomized Study.

ABSTRACT:

Purpose

Perioperative pain management plays a critical role in the effort to promote enhanced recovery after surgery (ERAS). Pain is also the most concern for patients after laparoscopic cholecystectomy (LC). Naldebain (extended-release dinalbuphine sebacate, DS) is an oil-based formulation for intramuscular injection that has been designed for extended release and can be used for preoperative analgesia over a 7-day period. This study was aimed to compare the efficacy of DS injection with that of regular postoperative morphine administered when necessary for the management of post-laparoscopic cholecystectomy pain.

Patients and methods

Forty-four patients scheduled for elective laparoscopic cholecystectomy were included in this prospective study. The patients were allocated

SUBMITTER: Lee SO 

PROVIDER: S-EPMC7490073 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature