The Role of PON1 Variants in Disease Susceptibility in a Turkish Population.
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SUBMITTER: Abudayyak M
PROVIDER: S-EPMC7490120 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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The Role of <i>PON1</i> Variants in Disease Susceptibility in a Turkish Population.
Abudayyak Mahmoud M Boran Tuğçe T Tukel Rumeysa R Oztas Ezgi E Özhan Gül G
Global medical genetics 20200831 2
Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common <i>PON1</i> Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold interindividual variation among the same genotype. <i>PON1</i> genotypes were evaluated with the development of pancreatitis, colorectal cancer, and hypothyroidism in a hospital-based, case-control study. Individuals with rs662 <i>G</i> al ...[more]
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