Effect of procyanidins on lipid metabolism and inflammation in rats exposed to alcohol and iron.

ABSTRACT:

Background

Lifestyle involving uncontrolled alcohol consumption coupled regularly with red meat and other iron sources has detrimental effects on the liver, which in the long term, results in Alcoholic Liver Disease (ALD). Procyanidin has lately garnered increasing attention and has become the focus of research owing to its antioxidant properties. This study explores the anti-inflammatory effects of procyanidins, in preventing ALD, by analyzing the biological activities of the compound on liver injury caused by excessive alcohol and iron.

Method

Male SPF Wistar rats were placed in 4 groups; the control Group A (basic diet); the model Group B (excess alcohol 8-12 mL/kg/d and iron 1000 mg/kg diet); the low dose procyanidin Group C (model group diet plus 60 mg/kg/d of procyanid

SUBMITTER: Lobo A 

PROVIDER: S-EPMC7490533 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature