Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients.

ABSTRACT: Brain ageing is thought to be related to geriatric depression, but the relationship between ageing and depression among middle aged individuals is unknown. The present study aimed to evaluate whether the age-related reduction of brain cortical thickness (CT) can be found in adult first-episode MDD patients, as well as to identify the possible genetic effect of the ANK3 gene polymorphism age-relates CT reduction. This study recruited 153 first-episode MDD patients with a disease duration < 2 years and 276 healthy controls (HC), and the CT of 68 whole brain regions and two ANK3 SNPs (rs1994336 and rs10994359) were analyzed. The results showed that although the CT of both groups was negative correlated with age, the MDD group had significant greater age-related decrease in CT than the HC grou

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC7490581 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature