Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.

ABSTRACT: The initiation of an intestinal tumour is a probabilistic process that depends on the competition between mutant and normal epithelial stem cells in crypts¹. Intestinal stem cells are closely associated with a diverse but poorly characterized network of mesenchymal cell types^2,3. However, whether the physiological mesenchymal microenvironment of mutant stem cells affects tumour initiation remains unknown. Here we provide in vivo evidence that the mesenchymal niche controls tumour initiation in trans. By characterizing the heterogeneity of the intestinal mesenchyme using single-cell RNA-sequencing analysis, we identified a population of rare pericryptal Ptgs2-expressing fibroblasts that constitutively process arachidonic acid into highly labile prostaglandin E₂

SUBMITTER: Roulis M 

PROVIDER: S-EPMC7490650 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature