Genomic Signatures in Luminal Breast Cancer.

ABSTRACT:

Background

Breast cancer is a very heterogeneous disease and luminal breast carcinomas represent the hormone receptor-positive tumors among all breast cancer subtypes. In this context, multigene signatures were developed to gain further prognostic and predictive information beyond clinical parameters and traditional immunohistochemical markers.

Summary

For early breast cancer patients these molecular tools can guide clinicians to decide on the extension of endocrine therapy to avoid over- and undertreatment by adjuvant chemotherapy. Beside the predictive and prognostic value, a few genomic tests are also able to provide intrinsic subtype classification. In this review, we compare the most frequently used and commercially available molecular tests (OncotypeDX®, MammaPrint®, P

SUBMITTER: Puppe J 

PROVIDER: S-EPMC7490652 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature