Glutamatergic modulation of auditory cortex connectivity with attentional brain networks in unpredictable perceptual environment.

ABSTRACT: In a stable environment the brain can minimize processing required for sensory input by forming a predictive model of the surrounding world and suppressing neural response to predicted stimuli. Unpredicted stimuli lead to a prediction error signal propagation through the perceptual network, and resulting adjustment to the predictive model. The inter-regional plasticity which enables the model-building and model-adjustment is hypothesized to be mediated via glutamatergic receptors. While pharmacological challenge studies with glutamate receptor ligands have demonstrated impact on prediction-error indices, it is not clear how inter-individual differences in the glutamate system affect the prediction-error processing in non-medicated state. In the present study we examined 20 healthy young su

SUBMITTER: Kompus K 

PROVIDER: S-EPMC7490710 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature