Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer.

ABSTRACT: As an important posttranscriptional modification of RNA, 5-methylcytosine (m⁵C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m⁵C modification in multiple cellular processes as well as tumorigenesis. Cooperatively, advances in m⁵C detection techniques have enabled transcriptome mapping of RNA methylation at single-nucleotide resolution, thus stimulating m⁵C-based investigations. In this review, we summarize currently available approaches for detecting m⁵C distribution in RNA as well as the advantages and disadvantages of these techniques. Moreover, we elucidate the regulatory mechanisms of RNA m⁵C modification by introducing the molecular structure, catalytic substra

SUBMITTER: Xue C 

PROVIDER: S-EPMC7490858 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature