Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling.

ABSTRACT:

Background

The increasing age of global populations highlights the urgent need to understand the biological underpinnings of ageing. To this end, inhibition of the insulin/insulin-like signalling (IIS) pathway can extend healthy lifespan in diverse animal species, but with trade-offs including delayed development. It is possible that distinct cell types underlie effects on development and ageing; cell-type-specific strategies could therefore potentially avoid negative trade-offs when targeting diseases of ageing, including prevalent neurodegenerative diseases. The highly conserved diversity of neuronal and non-neuronal (glial) cell types in the Drosophila nervous system makes it an attractive system to address this possibility. We have thus investigated whether IIS in distinct glia

SUBMITTER: Woodling NS 

PROVIDER: S-EPMC7490873 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature