Study on metastasis inhibition of Kejinyan decoction on lung cancer by affecting tumor microenvironment.

ABSTRACT:

Background

Kejinyan decoction, as an experienced formula of Zhou Zhongying (the Master of Traditional Chinese Medicine) has been widely used in clinic for lung cancer treatment in China, while the anti-lung cancer mechanism of it is still remained to be elucidated. Herein, our basic study found that the survival of lung cancer xenograft mice was significantly prolonged after intragastrically administered high dose of Kejinyan decoction (3.8 g per kg BW) for 15 days. More importantly, we found that Kejinyan decoction inhibited the metastasis of lung cancer cells in vivo. Thus in this study, we aim to elucidate the anti-metastasis effects of Kejinyan decoction.

Methods

RNA-Seq was used to find out the gene regulation of Kejinyan decoction on the mice, flow cytometry assay was

SUBMITTER: Chen M 

PROVIDER: S-EPMC7490898 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature