Correlation of the two most frequent HLA haplotypes in the Italian population to the differential regional incidence of Covid-19.

ABSTRACT:

Background

Understanding how HLA polymorphisms may affect both susceptibility, course and severity of Covid-19 infection could help both at the clinical level to identify individuals at higher risk from the disease and at the epidemiological one to explain the differences in the epidemic trend among countries or even within a specific country. Covid-19 disease in Italy showed a peculiar geographical distribution from the northern most affected regions to the southern ones only slightly touched.

Methods

In this study we analysed the regional frequencies for the most common Italian haplotypes from the Italian Bone Marrow Donor Registry (HLA-A, -B, -C and -DRB1 at four-digit level). Then we performed Pearson correlation analyses among regional haplotypes estimated frequency in

SUBMITTER: Pisanti S 

PROVIDER: S-EPMC7491019 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature