Role of TG2 and TGF-β₁ in the pathogenesis of human breast cancer.

ABSTRACT: The present study analyzed the role of transforming growth factor-β₁ (TGF-β₁) and tissue transglutaminase (TG2) in breast cancer, as well as their protein levels in MCF-7 cells treated with cisplatin. In addition, the present study investigated the effects of TG2 and TGF-β₁ in MCF-7 cells following TGF-β₁ and TG2 inhibition or TGF-β₁ induction. The protein levels of TG2 and TGF-β₁ in breast cancer tissues and in MCF-7 cells treated with cisplatin, TG2 and TGF-β₁ inhibitors or 10 ng/ml TGF-β₁ were analyzed by immunohistochemical staining, immunofluorescence and western blotting. The results revealed that the expression levels of TG2 and TGF-β₁ in breast cancer tissues were significantly higher

SUBMITTER: Gao HC 

PROVIDER: S-EPMC7491046 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature