Oxytocin-enhanced group therapy for methamphetamine use disorder: Randomized controlled trial.

ABSTRACT:

Background

Methamphetamine (METH) use is a public health crisis that disproportionately affects men who have sex with men (MSM). There are currently no FDA-approved pharmacological interventions to treat methamphetamine use disorder (MUD). MUD is associated with social impairments and extremely high treatment attrition rates. Administration of oxytocin, a neuropeptide involved in social attachment, may be a novel approach to addressing these issues. Moreover, oxytocin administration has shown promise for reducing METH-related addictive behavior in animal models, but has not yet been investigated in clinical trials for MUD. Last, oxytocin is known to modulate stress responsivity via regulation of the autonomic nervous system, which is dysregulated in METH users. We hypothesize that

SUBMITTER: Stauffer CS 

PROVIDER: S-EPMC7491413 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature