Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study.

ABSTRACT: Cardiovascular health in midlife is an established risk factor for cognitive function later in life. Knowing mechanisms of this association may allow preventative steps to be taken to preserve brain health and cognitive performance in older age. In this study, we investigated the association of the Framingham stroke-risk score, a validated multifactorial predictor of 10-year risk of stroke, with brain measures and cognitive performance in stroke-free individuals. We used a large (N = 800) longitudinal cohort of community-dwelling adults of the Whitehall II imaging sub-study with no obvious structural brain abnormalities, who had Framingham stroke risk measured five times between 1991 and 2013 and MRI measures of structural integrity, and cognitive function performed between 2012 and

SUBMITTER: Zsoldos E 

PROVIDER: S-EPMC7491431 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature