Hypertension and the roles of the 9p21.3 risk locus: Classic findings and new association data.

ABSTRACT:

Background

The band 9p21.3 contains an established genomic risk zone for cardiovascular disease (CVD). Since the initial 2007 Wellcome Trust Case Control Consortium study (WTCCC), the increased CVD risk associated with 9p21.3 has been confirmed by multiple studies in different continents. However, many years later there was still no confirmed report of a corresponding association of 9p21.3 with hypertension, a major CV risk factor, nor with blood pressure (BP).

Theory

In this contribution, we review the bipartite haplotype structure of the 9p21.3 risk locus: one block is devoid of protein-coding genes but contains the lead CVD risk SNPs, while the other block contains the first exon and regulatory DNA of the gene for the cell cycle inhibitor p15. We consider how findings fro

SUBMITTER: Gallo JE 

PROVIDER: S-EPMC7491459 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature