Use of MSCs and MSC-educated macrophages to mitigate hematopoietic acute radiation syndrome.

ABSTRACT:

Purpose of review

Innovative and minimally toxic treatment approaches are sorely needed for the prevention and treatment of hematopoietic acute radiation syndrome (H-ARS). Cell therapies have been increasingly studied for their potential use as countermeasures for accidental and intentional ionizing radiation exposures which can lead to fatal ARS. Mesenchymal stem/stromal cells (MSCs) are a cell therapy that have shown promising results in preclinical studies of ARS, and are being developed in clinical trials specifically for H-ARS. MSCs, MSC-educated macrophages (MEMs) and MSC-exosome educated macrophages (EEMs) all have the potential to be used as adoptive cell therapies for H-ARS. Here we review how MSCs have been reported to mitigate inflammation from radiation injury while als

SUBMITTER: Chinnadurai R 

PROVIDER: S-EPMC7491866 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature