Macrolide and Nonmacrolide Resistance with Mass Azithromycin Distribution.

ABSTRACT:

Background

Mass distribution of azithromycin to preschool children twice yearly for 2 years has been shown to reduce childhood mortality in sub-Saharan Africa but at the cost of amplifying macrolide resistance. The effects on the gut resistome, a reservoir of antimicrobial resistance genes in the body, of twice-yearly administration of azithromycin for a longer period are unclear.

Methods

We investigated the gut resistome of children after they received twice-yearly distributions of azithromycin for 4 years. In the Niger site of the MORDOR trial, we enrolled 30 villages in a concurrent trial in which they were randomly assigned to receive mass distribution of either azithromycin or placebo, offered to all children 1 to 59 months of age every 6 months for 4 years. Rectal swab

SUBMITTER: Doan T 

PROVIDER: S-EPMC7492079 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature