SARS-CoV-2 identification and IgA antibodies in saliva: One sample two tests approach for diagnosis.

ABSTRACT:

Aim

This study aims to verify whether standardized saliva collection is suitable for SARS-CoV-2 molecular detection and IgA measurement.

Methods

43 COVID-19 inpatients and 326 screening subjects underwent naso-pharyngeal (NP)-swab and saliva collection (Salivette). Inpatients also underwent repeated blood collections to evaluate inflammation and organs involvement. In all patients and subjects, SARS-CoV-2 (gene E) rRT-PCR was undertaken in saliva and NP-swabs. Salivary IgA and serum IgA, IgG, IgM were measured on inpatients' samples.

Results

NP-swabs and saliva were both SARS-CoV-2 positive in 7 (16%) or both negative in 35 (82%) out of 43 patients successfully included in the study. NP-swabs and saliva results did not perfectly match in one patient (saliva positive,

SUBMITTER: Aita A 

PROVIDER: S-EPMC7492139 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature