Prognostic value of nucleotyping, DNA ploidy and stroma in high-risk stage II colon cancer.

ABSTRACT:

Background

Heterogeneity with respect to recurrence and survival in high-risk stage II colon cancer patients still exists, and further classification is urgently required. This study aimed to ascertain the prognostic value of DNA ploidy, stroma-tumour fraction and nucleotyping in the prognosis of high-risk stage II colon cancer.

Methods

A total of 188 high-risk stage II colon cancer patients received radical surgery in Peking University Cancer Hospital, from 2009 to 2015. Status of mismatch repair proteins in tumours was analysed using immunohistochemistry. DNA ploidy, stroma-tumour fraction and nucleotyping were estimated by automated digital imaging systems.

Results

Nucleotyping and DNA ploidy were significant prognostic factors, while stroma-tumour fraction were no

SUBMITTER: Yang L 

PROVIDER: S-EPMC7492254 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature