Controlled ovarian stimulation and progesterone supplementation affect vaginal and endometrial microbiota in IVF cycles: a pilot study.

ABSTRACT:

Purpose

Does controlled ovarian stimulation (COS) and progesterone (P) luteal supplementation modify the vaginal and endometrial microbiota of women undergoing in vitro fertilization?

Methods

Fifteen women underwent microbiota analysis at two time points: during a mock transfer performed in the luteal phase of the cycle preceding COS, and at the time of fresh embryo transfer (ET). A vaginal swab and the distal extremity of the ET catheter tip were analyzed using next-generation 16SrRNA gene sequencing. Heterogeneity of the bacterial microbiota was assessed according to both the Bray-Curtis similarity index and the Shannon diversity index.

Results

Lactobacillus was the most prevalent genus in the vaginal samples, although its relative proportion was reduced by COS plus

SUBMITTER: Carosso A 

PROVIDER: S-EPMC7492325 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature