Association between mitochondrial DNA D-loop region polymorphisms and endometriosis in a Chinese population.

ABSTRACT:

Objective

To investigate the correlation between endometriosis and mitochondrial DNA (mtDNA) D-loop single nucleotide polymorphisms (SNPs) and haplotype, as well as the predictive power of certain SNPs in reproductive outcomes in a Chinese Han population.

Methods

A case-control study was conducted in which 125 endometriosis patients and 124 controls were recruited from an academic fertility center. The entire 1124-bp D-loop region of mtDNA of whole blood samples from all subjects was amplified, sequenced, and compared with the revised Cambridge Reference Sequence (rCRS) to identify SNPs and haplotypes. The association between D-loop SNPs and embryo quality and clinical outcome following in vitro fertilization (IVF) was also assessed.

Results

A total of 321 polymorphis

SUBMITTER: Li X 

PROVIDER: S-EPMC7492337 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature