Healthy live births from transfer of low-mosaicism embryos after preimplantation genetic testing for aneuploidy.

ABSTRACT:

Purpose

This study evaluated the potential viability of embryos with low mosaicism level (< 50%) by comparing the clinical outcomes of single mosaic versus euploid blastocyst transfer. In addition, the live birth outcomes for various types of mosaicism with respect to abnormalities in chromosome structure and content were analyzed.

Methods

This study included patients who underwent in vitro fertilization with preimplantation genetic testing for aneuploidy (PGT-A). The PGT-A cycles performed through next-generation sequencing with single euploid or mosaic embryo transfers were included. We collected 299 frozen single embryo transfer cycles-216 single euploid and 83 mosaic-between July 2016 and July 2018. This study analyzed clinical outcomes, including fetal karyotyping by us

SUBMITTER: Lee CI 

PROVIDER: S-EPMC7492347 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature