Quantile-specific heritability of high-density lipoproteins with implications for precision medicine.

ABSTRACT:

Background

We have previously shown that the effect of a high-density lipoprotein (HDL) genetic risk score depends on whether the phenotype (HDL cholesterol) is high or low relative to its distribution (quantile-dependent expressivity).

Objective

Evidence for quantile-dependent expressivity was sought using a more inclusive genetic measure (quantile-specific heritability, h²) in a larger population (Framingham cohort).

Methods

Quantile regression was used to test whether the offspring-parent (β_OP) and full-sib (β_FS) regression slopes increased with the percentiles of the offspring's HDL distribution in 10,650 parent-offspring pairs and 2130 sibships. Quantile-specific heritability was estimated by 2β_OP/(1 + r_spouse

SUBMITTER: Williams PT 

PROVIDER: S-EPMC7492391 | biostudies-literature | 2020 Jul - Aug

REPOSITORIES: biostudies-literature