Metabolomics profiling of tobacco exposure in children with cystic fibrosis.

ABSTRACT:

Background

Inflammation is integral to early disease progression in children with CF. The effect of modifiable environmental factors on infection and inflammation in persons with CF is poorly understood. Our prior studies determined that secondhand smoke exposure (SHSe) is highly prevalent in young children with CF. SHSe is associated with increased inflammation, heightened bacterial burden, and worsened clinical outcomes. However, the specific metabolite and signaling pathways that regulate responses to SHSe in CF are relatively unknown.

Methods

High-resolution metabolomics was performed on plasma samples from infants (n = 25) and children (n = 40) with CF compared to non-CF controls (n = 15). CF groups were stratified according to infant or child age and SHSe status.

Re

SUBMITTER: Wisniewski BL 

PROVIDER: S-EPMC7492400 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature