An epigenome-wide association study of ambient pyrethroid pesticide exposures in California's central valley.

ABSTRACT:

Background

Pyrethroid pesticide use is increasing worldwide, although the full extent of associated health effects is unknown. An epigenome-wide association study (EWAS) with exploratory pathway analysis may help identify potential pyrethroid-related health effects.

Methods

We performed an exploratory EWAS of chronic ambient pyrethroid exposure using control participants' blood in the Parkinson's Environment and Genes Study in the Central Valley of California (N = 237). We estimated associations of living and working near agricultural pyrethroid pesticide applications in the past 5 years (binary) with site-specific differential methylation, and used a false discovery rate (FDR) cut off of 0.05 for significance. We controlled for age, sex, education, cell count, and an ancest

SUBMITTER: Furlong MA 

PROVIDER: S-EPMC7492449 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature