Preclinical evaluation of a pediatric airway stent for tracheobronchomalacia.

ABSTRACT:

Objectives

We sought to demonstrate in an animal model that helical stents made from a nickel titanium alloy called nitinol (NiTi) and designed for malacic airways could be delivered and removed without significant trauma while minimally impeding mucus clearance during the period of implantation.

Methods

Stents were delivered and removed from the tracheas of healthy 20 kg swine (n = 5) using tools designed to minimize trauma. In 4-week experiments, the stents were implanted on day 0, removed after 3 weeks, and swine were put to death after 4 weeks. Weekly bronchoscopies, radiographs, and mucus clearance examinations were performed in vivo. Hematoxylin and eosin staining and scanning electron microscopy imaging were used to evaluate foreign body response, tracheal tissue reac

SUBMITTER: Mondal A 

PROVIDER: S-EPMC7492470 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature