Fibrocyte accumulation in the lungs of cystic fibrosis patients.

ABSTRACT:

Background

Cystic fibrosis (CF) patients develop severe lung disease including chronic airway infections, neutrophilic inflammation, and progressive fibrotic remodeling in airways. However, cellular and molecular processes that regulate excessive collagen deposition in airways in these patients remain unclear. Fibrocytes are bone marrow (BM)-derived mesenchymal cells that express the hematopoietic cell marker CD45, and mesenchymal cell markers and implicated in collagen deposition in several fibrotic diseases. It is unknown whether fibrocytes accumulate in the lungs of CF patients, so the current study evaluates the presence of fibrocytes in the fibrotic lesions of airways in explanted CF lungs compared to non-CF unused donor lungs (control).

Methods

We used immunofluorescen

SUBMITTER: Kasam RK 

PROVIDER: S-EPMC7492481 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature