Antigen-Specific CD4⁺ T Cells Exhibit Distinct Kinetic and Phenotypic Patterns During Primary and Secondary Responses to Infection.

ABSTRACT: Although CD4⁺ T cell memory is a critical component of adaptive immunity, antigen-specific CD4⁺ T cell recall responses to secondary infection have been inadequately studied. Here we examine the kinetics of the secondary response in an important immunological model, infection with attenuated Listeria monocytogenes (Lm). We identify CD4⁺ T cell subsets that preferentially expand during a secondary response and highlight the importance of prime-boost strategies in expanding and maintaining antigen-specific, tissue-resident memory CD4⁺ T cells. Following intravenous infection with an attenuated strain of Lm, we found that total antigen-specific CD4⁺ T cells responded more robustly in secondary compared with primary infection, reach

SUBMITTER: Malhotra D 

PROVIDER: S-EPMC7492679 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature