Melanoma Prognosis: Accuracy of the American Joint Committee on Cancer Staging Manual Eighth Edition.

ABSTRACT:

Background

The American Joint Committee on Cancer (AJCC) maintains that the eighth edition of its Staging Manual (AJCC8) has improved accuracy compared with the seventh (AJCC7). However, there are concerns that implementation may disrupt analysis of active clinical trials for stage III patients. We used an independent cohort of melanoma patients to test the extent to which AJCC8 has improved prognostic accuracy compared with AJCC7.

Methods

We analyzed a cohort of 1315 prospectively enrolled patients. We assessed primary tumor and nodal classification of stage I-III patients using AJCC7 and AJCC8 to assign disease stages at diagnosis. We compared recurrence-free (RFS) and overall survival (OS) using Kaplan-Meier curves and log-rank tests. We then compared concordance indices

SUBMITTER: Bajaj S 

PROVIDER: S-EPMC7492758 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature