Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) linked with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause severe illness and life-threatening pneumonia in humans. The current COVID-19 pandemic demands an effective vaccine to acquire protection against the infection. Therefore, the present study was aimed to design a multiepitope-based subunit vaccine (MESV) against COVID-19.

Methods

Structural proteins (Surface glycoprotein, Envelope protein, and Membrane glycoprotein) of SARS-CoV-2 are responsible for its prime functions. Sequences of proteins were downloaded from GenBank and several immunoinformatics coupled with computational approaches were employed to forecast B- and T- cell epitopes from the SARS-CoV-2 highly antigenic structural proteins to design

SUBMITTER: Tahir Ul Qamar M 

PROVIDER: S-EPMC7492789 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature