An integrated exploration of pharmacological potencies of Bischofia javanica (Blume) leaves through experimental and computational modeling.

ABSTRACT: Bischofia javanica (Blume), an edible wild plant, has both prospective nutraceutical and therapeutic properties. Here, we intended to explore the pharmacological potentials of the methanol extract of B. javanica (MEBJ) through integrated approaches. Phytochemical screening revealed the presence of important phytoconstituents which were found to be safe during cytotoxicity analysis. The sedative potential of MEBJ (200 and 400 mg/kg) was determined by employing open field, hole cross, and thiopental sodium-induced sleeping time tests, where a significant reduction of the locomotor performance and an enhancement in the duration of sleeping have been observed, respectively. In addition, mice treated with MEBJ exhibited superior exploration during both elevated plus maze and hole

SUBMITTER: Chowdhury MR 

PROVIDER: S-EPMC7492998 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature