Dataset Information

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01_E vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention.

ABSTRACT:

Introduction

Seasonal malaria chemoprevention (SMC), with sulphadoxine-pyrimethamine plus amodiaquine (SP+AQ) is effective but does not provide complete protection against clinical malaria. The RTS,S/AS01_E malaria vaccine provides a high level of protection shortly after vaccination, but this wanes rapidly. Such a vaccine could be an alternative or additive to SMC. This trial aims to determine whether seasonal vaccination with RTS,S/AS01_E vaccine could be an alternative to SMC and whether a combination of the two interventions would provide added benefits.

Methods and analysis

This is an individually randomised, double-blind, placebo-controlled trial. 5920 children aged 5-17 months were enrolled in April 2017 in Mali and Burkina Faso. Children in group

SUBMITTER: Chandramohan D

PROVIDER: S-EPMC7493088 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Dataset Information

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01_E vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention.

Introduction

Methods and analysis

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01E vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention.

Introduction

Methods and analysis

OmicsDI is part of the ELIXIR infrastructure

Tweets

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01_E vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention.