Cannabidiol attenuates the rewarding effects of cocaine in rats by CB2, 5-HT_1A and TRPV1 receptor mechanisms.

ABSTRACT: Cocaine abuse continues to be a serious health problem worldwide. Despite intense research there is currently no FDA-approved medication to treat cocaine use disorder. The recent search has been focused on agents targeting primarily the dopamine system, while limited success has been achieved at the clinical level. Cannabidiol (CBD) is a U.S. FDA-approved cannabinoid for the treatment of epilepsy and recently was reported to have therapeutic potential for other disorders. Here we systemically evaluated its potential utility for the treatment of cocaine use disorder and explored the underlying receptor mechanisms in experimental animals. Systemic administration (10-40 mg/kg) of CBD dose-dependently inhibited cocaine self-administration, shifted a cocaine dose-response curve downward, and lo

SUBMITTER: Galaj E 

PROVIDER: S-EPMC7493134 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature