Independent and joint cross-sectional associations of statin and metformin use with mammographic breast density.

ABSTRACT:

Background

Well-tolerated and commonly used medications are increasingly assessed for reducing breast cancer risk. These include metformin and statins, both linked to reduced hormone availability and cell proliferation or growth and sometimes prescribed concurrently. We investigated independent and joint associations of these medications with mammographic breast density (MBD), a useful biomarker for the effect of chemopreventive agents on breast cancer risk.

Methods

Using data from a cross-sectional study of 770 women (78% Hispanic, aged 40-61 years, in a mammography cohort with high cardiometabolic burden), we examined the association of self-reported "ever" use of statins and metformin with MBD measured via clinical Breast Imaging Reporting and Data System (BI-RADS) densit

SUBMITTER: Lee Argov EJ 

PROVIDER: S-EPMC7493153 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature