Reducing Glut2 throughout the body does not result in cognitive behaviour differences in aged male mice.

ABSTRACT:

Objectives

GLUT2 is a major facilitative glucose transporter, expressed from the SLC2A2 gene, with essential roles in the liver. Recent work in mice has shown that preventing Glut2 production in specific neuronal populations increases sugar-seeking behaviour, highlighting the importance of Slc2a2 gene expression in the brain. It implies that reduced GLUT2 in the brain, due to genetic polymorphisms or disease, impacts health through behaviour change. Defects in glucose transport in the brain are observed in conditions including type-2 diabetes and dementia. Few studies have directly examined the effect of modulating neuronal glucose transporter expression on cognitive function. The aim of this study was to investigate whether inactivating one Slc2a2 allele throughout the body had ma

SUBMITTER: Morrice N 

PROVIDER: S-EPMC7493158 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature