Distributed causality in resting-state network connectivity in the acute and remitting phases of RRMS.

ABSTRACT:

Background

Although previous studies have shown that intra-network abnormalities in brain functional networks are correlated with clinical/cognitive impairment in multiple sclerosis (MS), there is little information regarding the pattern of causal interactions among cognition-related resting-state networks (RSNs) in different disease stages of relapsing-remitting MS (RRMS) patients. We hypothesized that abnormalities of causal interactions among RSNs occurred in RRMS patients in the acute and remitting phases.

Methods

Seventeen patients in the acute phases of RRMS, 24 patients in the remitting phases of RRMS, and 23 appropriately matched healthy controls participated in this study. First, we used group independent component analysis to extract the time courses of the spatial

SUBMITTER: Wu L 

PROVIDER: S-EPMC7493168 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature