Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study.

ABSTRACT:

Background

Cognition in the elderly is heterogeneous. Senescence of the immune system is increasingly considered as a potential player in cognitive performance. We explored here the interplay between cognitive performance and peripheral immune molecules in healthy older individuals.

Methods

A cross-sectional study of clinically well characterized senior healthy individuals (120; 51-87 years old) previously clustered as "Good" and "Poor" performers based on established tests that evaluate memory and executive function. A plasma concentration of 30 immune molecules was assessed by multiplex analysis and correlated with parameters of cognitive performance.

Results

Participants with worse cognitive performance ("Poor") exhibited increased concentrations of IL-1β, IL-8, IL

SUBMITTER: Serre-Miranda C 

PROVIDER: S-EPMC7493640 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature