Plasma Exchange: An Effective Rescue Therapy in Critically Ill Patients With Coronavirus Disease 2019 Infection.

ABSTRACT:

Objectives

Infection by severe acute respiratory syndrome coronavirus-2 can induce uncontrolled systemic inflammation and multiple organ failure. The aim of this study was to evaluate if plasma exchange, through the removal of circulating mediators, can be used as rescue therapy in these patients.

Design

Single center case series.

Setting

Local study.

Subjects

Four critically ill adults with coronavirus disease 19 pneumonia that failed conventional interventions.

Interventions

Plasma exchange. Two to six sessions (1.2 plasma volumes). Human albumin (5%) was used as the main replacement fluid. Fresh frozen plasma and immunoglobulins were administered after each session to avoid coagulopathy and hypogammaglobulinemia.

Measurements and main results

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SUBMITTER: Fernandez J 

PROVIDER: S-EPMC7493773 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature