Quantification of Factor H Mediated Self vs. Non-self Discrimination by Mathematical Modeling.

ABSTRACT: The complement system is part of the innate immune system and plays an important role in the host defense against infectious pathogens. One of the main effects is the opsonization of foreign invaders and subsequent uptake by phagocytosis. Due to the continuous default basal level of active complement molecules, a tight regulation is required to protect the body's own cells (self cells) from opsonization and from complement damage. A major complement regulator is Factor H, which is recruited from the fluid phase and attaches to cell surfaces where it effectively controls complement activation. Besides self cells, pathogens also have the ability to bind Factor H; they can thus escape opsonization and phagocytosis causing severe infections. In order to advance our understanding of the opsoniz

SUBMITTER: Tille A 

PROVIDER: S-EPMC7493836 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature