MiRTissue _ce: extending miRTissue web service with the analysis of ceRNA-ceRNA interactions.

ABSTRACT:

Background

Non-coding RNAs include different classes of molecules with regulatory functions. The most studied are microRNAs (miRNAs) that act directly inhibiting mRNA expression or protein translation through the interaction with a miRNAs-response element. Other RNA molecules participate in the complex network of gene regulation. They behave as competitive endogenous RNA (ceRNA), acting as natural miRNA sponges to inhibit miRNA functions and modulate the expression of RNA messenger (mRNA). It became evident that understanding the ceRNA-miRNA-mRNA crosstalk would increase the functional information across the transcriptome, contributing to identify new potential biomarkers for translational medicine.

Results

We present miRTissue _ce, an improvement of our original m

SUBMITTER: Fiannaca A 

PROVIDER: S-EPMC7493844 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature